Abstract
The vacA genotypes s1,m1 and s1,m2 were detected in 44 and 30% of Helicobacter pylori isolates, respectively, from patients with gastric mucosa-associated lymphoid tissue lymphoma, compared to 26 and 56% of isolates, respectively, from individuals with gastritis. The vacA s1 genotype was significantly associated with, but not predictive of, the presence of vacuolating cytotoxin activity.
MeSH terms
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Bacterial Proteins / genetics*
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Cytotoxins / metabolism*
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Female
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Gastritis / microbiology
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Genotype
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Helicobacter Infections / complications
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Helicobacter pylori / genetics*
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Helicobacter pylori / isolation & purification
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Helicobacter pylori / pathogenicity*
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Humans
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Lymphoma, B-Cell, Marginal Zone / complications
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Lymphoma, B-Cell, Marginal Zone / microbiology*
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Male
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Middle Aged
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Polymerase Chain Reaction / methods
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Stomach Neoplasms / complications
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Stomach Neoplasms / microbiology*
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Vacuoles / metabolism
Substances
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Bacterial Proteins
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Cytotoxins
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VacA protein, Helicobacter pylori