NK cells can recognize different forms of class I MHC

J Immunol. 1998 Jul 15;161(2):755-66.

Abstract

NK recognition and lysis of targets are mediated by activation receptor(s) whose effects may be over-ridden by inhibitory receptors recognizing class I MHC on the target. Incubation of normal lymphoblasts with a peptide that can bind to their class I MHC renders them sensitive to lysis by syngeneic NK cells. By binding to class I MHC, the peptide alters or masks the target structure recognized by an inhibitory NK receptor(s). This target structure is most likely an "empty" dimer of class I heavy chain and beta2m as opposed to a "full" class I trimer formed by binding of specific peptide that is recognized by CTL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Antigens, Ly*
  • Antigens, Surface / metabolism
  • Brefeldin A
  • Concanavalin A / pharmacology
  • Cyclopentanes / pharmacology
  • Cytotoxicity Tests, Immunologic
  • Cytotoxicity, Immunologic / drug effects
  • H-2 Antigens / metabolism
  • Histocompatibility Antigens Class I / biosynthesis
  • Histocompatibility Antigens Class I / drug effects
  • Histocompatibility Antigens Class I / metabolism*
  • Killer Cells, Natural / drug effects
  • Killer Cells, Natural / immunology*
  • Killer Cells, Natural / metabolism
  • Lectins, C-Type
  • Lymphocyte Activation
  • Macrolides
  • Membrane Glycoproteins / metabolism
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Nude
  • Molecular Sequence Data
  • Peptide Fragments / immunology
  • Peptide Fragments / metabolism
  • Protein Binding / immunology
  • Protein Synthesis Inhibitors / pharmacology
  • Receptors, Immunologic / immunology
  • Receptors, KIR
  • Receptors, NK Cell Lectin-Like
  • T-Lymphocytes, Cytotoxic / immunology
  • Time Factors

Substances

  • Anti-Bacterial Agents
  • Antigens, Ly
  • Antigens, Surface
  • Cyclopentanes
  • H-2 Antigens
  • Histocompatibility Antigens Class I
  • Lectins, C-Type
  • Macrolides
  • Membrane Glycoproteins
  • Peptide Fragments
  • Protein Synthesis Inhibitors
  • Receptors, Immunologic
  • Receptors, KIR
  • Receptors, NK Cell Lectin-Like
  • Concanavalin A
  • Brefeldin A