High-dose chemotherapy and autologous transplantation in lymphomatous polyposis in second remission: three case reports and literature review

Bone Marrow Transplant. 1998 Jul;22(1):103-6. doi: 10.1038/sj.bmt.1701265.

Abstract

Lymphomatous polyposis is a rare primary gastrointestinal lymphoma. It morphologically and immunohistochemically resembles mantle cell lymphoma, with which it shares a disappointing response rate and duration following conventional anthracyclin-containing combination chemotherapy, with a short median survival and virtually no long-term survivors. We report the use of high-dose chemotherapy with autologous stem cell transplantation in second partial remission in three patients with lymphomatous polyposis treated at the Royal Marsden Hospital. All patients achieved a complete response, and one patient remains well and disease-free 64 months following transplantation and 76 months after diagnosis.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Carmustine / administration & dosage
  • Cisplatin / administration & dosage
  • Combined Modality Therapy
  • Cyclophosphamide / administration & dosage
  • Cytarabine / administration & dosage
  • Dexamethasone / administration & dosage
  • Doxorubicin / administration & dosage
  • Etoposide / administration & dosage
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Intestinal Polyps / drug therapy
  • Intestinal Polyps / therapy*
  • Lymphoma, B-Cell / drug therapy
  • Lymphoma, B-Cell / therapy*
  • Male
  • Melphalan / administration & dosage
  • Middle Aged
  • Prednisone / administration & dosage
  • Transplantation, Autologous
  • Vincristine / administration & dosage

Substances

  • Cytarabine
  • Vincristine
  • Etoposide
  • Dexamethasone
  • Doxorubicin
  • Cyclophosphamide
  • Cisplatin
  • Melphalan
  • Carmustine
  • Prednisone

Supplementary concepts

  • CHOP protocol
  • DHAP protocol