Abstract
Endothelin-1 is mainly synthesized by the vascular endothelial cells and acts on the vascular smooth muscle. Because of its vasoconstrictor and mitogenic effects it plays a role in the development of vascular diseases. In diabetes mellitus atherosclerosis is accelerated. The authors summarize the available data of the role of endothelin-1 in Type 1 and Type 2 diabetes mellitus and the development of diabetic complication.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Diabetes Complications*
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Diabetes Mellitus / physiopathology
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Diabetes Mellitus, Experimental / complications
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Diabetes Mellitus, Experimental / physiopathology
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Diabetes Mellitus, Type 1 / complications
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Diabetes Mellitus, Type 1 / physiopathology
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Diabetes Mellitus, Type 2 / complications
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Diabetes Mellitus, Type 2 / physiopathology
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Diabetic Angiopathies / etiology
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Diabetic Angiopathies / physiopathology
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Endothelin-1 / physiology*
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Humans
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Rats