Indole-2-carboxamide inhibitors of human liver glycogen phosphorylase

J Med Chem. 1998 Jul 30;41(16):2934-8. doi: 10.1021/jm980264k.

Authors

D J Hoover¹, S Lefkowitz-Snow, J L Burgess-Henry, W H Martin, S J Armento, I A Stock, R K McPherson, P E Genereux, E M Gibbs, J L Treadway

Affiliation

¹ Departments of Cardiovascular and Metabolic Diseases Medicinal Chemistry, Exploratory Medicinal Biology, and Cardiovascular and Metabolic Diseases Biology, Central Research Division, Pfizer Inc., Groton, Connecticut 06340, USA.

PMID: 9685232
DOI: 10.1021/jm980264k

No abstract available

MeSH terms

Administration, Oral
Animals
Blood Glucose / metabolism
Cell Line
Diabetes Mellitus, Type 2 / blood
Diabetes Mellitus, Type 2 / prevention & control
Enzyme Inhibitors / administration & dosage
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology
Glycogen / metabolism
Humans
Hypoglycemic Agents / administration & dosage
Hypoglycemic Agents / chemical synthesis*
Hypoglycemic Agents / chemistry
Hypoglycemic Agents / pharmacology
Indoles / administration & dosage
Indoles / chemical synthesis*
Indoles / chemistry
Indoles / pharmacology
Liver / cytology
Liver / enzymology*
Liver / metabolism
Mice
Mice, Obese
Phosphorylases / antagonists & inhibitors*
Recombinant Proteins / antagonists & inhibitors
Stereoisomerism
Structure-Activity Relationship

Substances

Blood Glucose
Enzyme Inhibitors
Hypoglycemic Agents
Indoles
Recombinant Proteins
Glycogen
Phosphorylases