Severe 5-fluorouracil toxicity caused by reduced dihydropyrimidine dehydrogenase activity due to heterozygosity for a G-->A point mutation

J Inherit Metab Dis. 1998 Jun;21(3):280-4. doi: 10.1023/a:1005384609289.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Adenine
  • Antimetabolites, Antineoplastic / adverse effects*
  • Antimetabolites, Antineoplastic / therapeutic use
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / enzymology*
  • Breast Neoplasms / genetics
  • Cells, Cultured
  • Dihydrouracil Dehydrogenase (NADP)
  • Female
  • Fluorouracil / adverse effects*
  • Fluorouracil / therapeutic use
  • Guanine
  • Heterozygote*
  • Humans
  • Leukocytes, Mononuclear / enzymology
  • Middle Aged
  • Oxidation-Reduction
  • Oxidoreductases / genetics*
  • Oxidoreductases / metabolism
  • Point Mutation*
  • Polymerase Chain Reaction
  • Transcription, Genetic

Substances

  • Antimetabolites, Antineoplastic
  • Guanine
  • Oxidoreductases
  • Dihydrouracil Dehydrogenase (NADP)
  • Adenine
  • Fluorouracil