Identification of novel mutation patterns in the parC gene of ciprofloxacin-resistant isolates of Neisseria gonorrhoeae

D L Trees; A L Sandul; W L Whittington; J S Knapp

doi:10.1128/AAC.42.8.2103

Identification of novel mutation patterns in the parC gene of ciprofloxacin-resistant isolates of Neisseria gonorrhoeae

Antimicrob Agents Chemother. 1998 Aug;42(8):2103-5. doi: 10.1128/AAC.42.8.2103.

Authors

D L Trees¹, A L Sandul, W L Whittington, J S Knapp

Affiliation

¹ Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.

Abstract

Of 65 ciprofloxacin-resistant, clinical isolates of Neisseria gonorrhoeae, 5 isolates exhibited ParC mutations previously undescribed in the gonococcus. For isolates containing two ParC mutations (the Ser-87-->Ile and Glu-91-->Gly mutations and the Gly-85-->Cys and Arg116-->Leu mutations) the MICs of ciprofloxacin (8.0 to 64.0 microg/ml) were higher than those for the isolate containing the single ParC mutation (Arg-116-->Leu; MIC, 1.0 microg/ml).

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Anti-Infective Agents / pharmacology*
Ciprofloxacin / pharmacology*
DNA Topoisomerase IV
DNA Topoisomerases, Type II / genetics*
Female
Genes, Bacterial*
Humans
Mutation*
Neisseria gonorrhoeae / drug effects
Neisseria gonorrhoeae / genetics*
Polymerase Chain Reaction

Substances

Anti-Infective Agents
Ciprofloxacin
DNA Topoisomerase IV
DNA Topoisomerases, Type II