Abstract
A total of 201 Staphylococcus aureus isolates were surveyed for susceptibility to ciprofloxacin and trovafloxacin. Of 66 methicillin-resistant isolates, 89% were ciprofloxacin resistant and 6% were also trovafloxacin resistant. Trovafloxacin-resistant strains had unusual patterns of quinoline resistance mutations in DNA topoisomerase genes, including two mutations in the A subunit (encoded by grlA) of topoisomerase IV.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / pharmacology*
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Ciprofloxacin / pharmacology
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DNA Topoisomerase IV
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DNA Topoisomerases, Type II / genetics*
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Drug Resistance, Microbial
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Fluoroquinolones*
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Humans
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Microbial Sensitivity Tests
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Mutation*
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Naphthyridines / pharmacology*
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / enzymology*
Substances
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Anti-Infective Agents
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Fluoroquinolones
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Naphthyridines
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Ciprofloxacin
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trovafloxacin
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DNA Topoisomerase IV
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DNA Topoisomerases, Type II
Associated data
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GENBANK/AF044066
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GENBANK/AF044067
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GENBANK/AF044068
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GENBANK/AF044069
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GENBANK/AF044070
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GENBANK/AF044071
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GENBANK/AF044072
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GENBANK/AF044073
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GENBANK/AF044074
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GENBANK/AF044075
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GENBANK/AF044897
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GENBANK/AF044898
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GENBANK/AF044899
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GENBANK/AF044900
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GENBANK/AF044901
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GENBANK/AF044902
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GENBANK/AF044903
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GENBANK/AF044904
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GENBANK/AF044905
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GENBANK/AF044906