[Treatment of hepatosplenic candidiasis with liposomal amphotericin B in a patient with acute leukemia; a case report of the experience of use of liposomal amphotericin B]

Kansenshogaku Zasshi. 1998 Jun;72(6):635-7. doi: 10.11150/kansenshogakuzasshi1970.72.635.
[Article in Japanese]

Abstract

We report a 26-year-old male patient with acute myelocytic leukemia and hepatosplenic candidiasis during his clinical course. His hepatosplenic candidiasis was refractoty to itraconazole and fluconazol. He developed serious side-effect such as renal dysfunction, when conventional amphotericin B was given. Then he was treated with liposomal amphotericin B (Abelcet). This therapy was safe and effective for him. He was able to be treated with 3075 mg of a liposomal amphotericin B. This was ten times as much as the dose of conventional amphotericin B which was given earlier until amphotericin B was stopped because of renal dysfunction. Liposomal amphotericin B seems to be a safe and effective therapy for systemic fungal infectin and should be considered more in Japan.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Amphotericin B / administration & dosage*
  • Antifungal Agents / administration & dosage*
  • Candidiasis / drug therapy*
  • Humans
  • Leukemia, Myeloid, Acute / complications*
  • Liposomes
  • Liver Abscess / drug therapy*
  • Male
  • Splenic Diseases / drug therapy*

Substances

  • Antifungal Agents
  • Liposomes
  • Amphotericin B