The General Well-Being Schedule (GWB) is a brief, reliable, and valid measure of subjective well-being that is widely used in research as an indicator of psychological health and dysfunction. The GWB is hypothesized to have six subscales or dimensions (anxiety, depression, positive well-being, self-control, vitality, and general health), but previous research has not yielded a consistent factor structure. Little attention has been paid to the reliability and validity of the GWB with Mexican-Americans, the fastest growing minority group in the U.S. The purpose of this study was to evaluate the reliability and validity of the GWB schedule with Mexican-American women involved in a community-based weight-loss study. Factor analysis indicated a four-factor solution. The GWB and the resulting factors demonstrated acceptable reliability and discriminability.