Abstract
To evaluate the efficacy of ganciclovir, foscarnet, or the combination of both for the treatment of cytomegalovirus polyradiculomyelopathy (CMV-PRAM), we reviewed the records of seven patients with AIDS, diagnosed with CMV-PRAM. Muscle strength was graded according to the Medical Research Council (MRC) scale. Response to treatment was also classified according to MRC scale, based on the degree of improvement in muscle strength. Six of 7 patients had a good response to treatment, reaching the MRC scale of 4, or improving at least 3 degrees in the same scale. CMV-PRAM may be treated with ganciclovir alone or in combination with foscarnet.
Publication types
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Clinical Trial
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Controlled Clinical Trial
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English Abstract
MeSH terms
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AIDS-Related Opportunistic Infections / complications*
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Adult
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Antiviral Agents / therapeutic use*
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Cytomegalovirus Infections / complications*
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Cytomegalovirus Infections / drug therapy
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Drug Therapy, Combination
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Electromyography
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Female
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Foscarnet / therapeutic use*
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Ganciclovir / therapeutic use*
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Humans
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Male
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Muscle Tonus / drug effects
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Polyradiculopathy / drug therapy*
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Polyradiculopathy / virology*
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Spinal Cord Diseases / drug therapy*
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Spinal Cord Diseases / virology*
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Treatment Outcome
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Urinary Retention / drug therapy
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Urinary Retention / virology
Substances
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Antiviral Agents
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Foscarnet
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Ganciclovir