Ceftriaxone-related fatal hemolysis in an adolescent with perinatally acquired human immunodeficiency virus infection

J Pediatr. 1998 Aug;133(2):279-81. doi: 10.1016/s0022-3476(98)70236-7.

Abstract

A 14-year-old girl with perinatally acquired human immunodeficiency virus infection had fatal intravascular hemolysis after intravenous administration of ceftriaxone. Laboratory studies confirmed the presence of an antibody against ceftriaxone in the serum and on the patient's red blood cells. No evidence of sepsis, glucose-6-phosphate dehydrogenase deficiency or anaphylaxis was found.

Publication types

  • Case Reports

MeSH terms

  • AIDS-Related Opportunistic Infections / drug therapy*
  • AIDS-Related Opportunistic Infections / immunology
  • Adolescent
  • Anemia, Hemolytic / chemically induced*
  • Anemia, Hemolytic / immunology
  • Antibodies
  • Ceftriaxone / adverse effects*
  • Ceftriaxone / immunology
  • Cephalosporins / adverse effects*
  • Cephalosporins / immunology
  • Fatal Outcome
  • Female
  • HIV Infections / complications
  • HIV Infections / immunology
  • Hemolysis / drug effects
  • Humans

Substances

  • Antibodies
  • Cephalosporins
  • Ceftriaxone