Beta interferon is produced by Chlamydia trachomatis-infected fibroblast-like synoviocytes and inhibits gamma interferon-induced HLA-DR expression

J Rödel; A Groh; H Vogelsang; M Lehmann; M Hartmann; E Straube

doi:10.1128/IAI.66.9.4491-4495.1998

Beta interferon is produced by Chlamydia trachomatis-infected fibroblast-like synoviocytes and inhibits gamma interferon-induced HLA-DR expression

Infect Immun. 1998 Sep;66(9):4491-5. doi: 10.1128/IAI.66.9.4491-4495.1998.

Authors

J Rödel¹, A Groh, H Vogelsang, M Lehmann, M Hartmann, E Straube

Affiliation

¹ Institute of Medical Microbiology, Friedrich Schiller University of Jena, D-07743 Jena, Germany. [email protected]

Abstract

Infection of fibroblast-like synovial cells with Chlamydia trachomatis (serotype D strain IC Cal 8) in culture induced the secretion of beta interferon (IFN-beta). Chlamydial infection inhibited IFN-gamma-induced expression of HLA-DR antigen in the cells. Addition of IFN-beta antibody directly to infected cultures mitigated HLA-DR inhibition, suggesting involvement of produced IFN-beta.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cells, Cultured
Chlamydia trachomatis / physiology*
Fibroblasts / metabolism*
Fibroblasts / microbiology
HLA-DR Antigens / biosynthesis*
Humans
Interferon-beta / metabolism*
Interferon-gamma / antagonists & inhibitors
Interferon-gamma / physiology*
Synovial Membrane / cytology

Substances

HLA-DR Antigens
Interferon-beta
Interferon-gamma