Acute myocardial infarction with large bilateral intracoronary thrombi in a young patient with the prothrombin 20210 G-->A mutation

Cathet Cardiovasc Diagn. 1998 Aug;44(4):427-30. doi: 10.1002/(sici)1097-0304(199808)44:4<427::aid-ccd15>3.0.co;2-f.

Abstract

A genetic variation in the 3'-UT region of the prothrombin gene, a G to A mutation at nucleotide 20210, has been associated recently with increased risk of acute myocardial infarction. We describe a case of a young patient carrying the mutation, with an AMI caused by large bilateral intracoronary thrombi, that underwent direct PTCA.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Base Sequence / genetics
  • Coronary Angiography
  • Coronary Thrombosis / blood
  • Coronary Thrombosis / genetics*
  • Coronary Thrombosis / therapy
  • DNA Mutational Analysis*
  • Electrocardiography
  • Genetic Carrier Screening
  • Genetic Variation
  • Humans
  • Male
  • Myocardial Infarction / blood
  • Myocardial Infarction / genetics*
  • Myocardial Infarction / therapy
  • Nucleotide Mapping
  • Pedigree
  • Prothrombin / genetics*
  • Prothrombin / metabolism
  • Thrombophilia / blood
  • Thrombophilia / genetics*
  • Thrombophilia / therapy

Substances

  • Prothrombin