Mechanisms of protein sorting and coat assembly: insights from the clathrin-coated vesicle pathway

Curr Opin Cell Biol. 1998 Aug;10(4):499-503. doi: 10.1016/s0955-0674(98)80065-3.

Abstract

Clathrin-coated vesicles have provided the best example illustrating how both soluble and membrane proteins are selectively clustered into a transport intermediate for subsequent delivery to another intracellular compartment. Like cytosolic clathrin adaptors, the adaptor-like complex AP-3 binds to specific membranes and selects membrane proteins by interacting with their sorting signals.

Publication types

  • Review

MeSH terms

  • Adaptor Protein Complex alpha Subunits
  • Adaptor Proteins, Vesicular Transport
  • Animals
  • Cell Membrane / metabolism
  • Clathrin / metabolism*
  • Coated Vesicles / metabolism*
  • Leucine / metabolism
  • Membrane Proteins / metabolism
  • Monomeric Clathrin Assembly Proteins*
  • Proteins / metabolism*
  • Tyrosine / metabolism

Substances

  • Adaptor Protein Complex alpha Subunits
  • Adaptor Proteins, Vesicular Transport
  • Clathrin
  • Membrane Proteins
  • Monomeric Clathrin Assembly Proteins
  • Proteins
  • clathrin assembly protein AP180
  • Tyrosine
  • Leucine