Abstract
Clonal anergy in Ag-specific CD4+ T cells is shown in these experiments to inhibit IL-2 production and clonal expansion in vivo. We also demonstrate that the defect in IL-2 gene inducibility can be achieved in both naive and Th1-like memory T cells when repeatedly exposed to aqueous peptide Ag. Nevertheless, this induction of clonal anergy did not interfere with the capacity of naive T cells to differentiate into Th1-like effector cells, nor did it prevent such helper cells from participating in T-dependent IgG2a anti-hapten responses and delayed-type hypersensitivity reactions. Thus, clonal anergy can contribute to the development of Ag-specific immune tolerance by limiting the size of a Th cell population, but not by disrupting its effector function.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adoptive Transfer
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Animals
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Antigens / administration & dosage
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Antigens / immunology
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Cell Differentiation / immunology
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Cell Movement / immunology
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Clonal Anergy / genetics
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Clonal Anergy / immunology*
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Hypersensitivity, Delayed / immunology
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Immunoglobulin G / biosynthesis
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Immunophenotyping
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Injections, Intravenous
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Interferon-gamma / biosynthesis
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Interleukin-2 / biosynthesis
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Interphase / immunology
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Lymph Nodes / cytology
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Lymph Nodes / immunology
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Lymphocyte Activation
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Lymphocyte Cooperation
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Mice
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Mice, Inbred BALB C
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Mice, Nude
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Mice, Transgenic
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Ovalbumin / administration & dosage
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Ovalbumin / immunology
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Peptide Fragments / administration & dosage
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Peptide Fragments / immunology
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Receptors, Antigen, T-Cell / genetics
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T-Lymphocyte Subsets / immunology
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T-Lymphocyte Subsets / metabolism
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T-Lymphocyte Subsets / transplantation
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Th1 Cells / immunology*
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Th1 Cells / metabolism
Substances
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Antigens
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Immunoglobulin G
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Interleukin-2
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OVA 323-339
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Peptide Fragments
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Receptors, Antigen, T-Cell
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Interferon-gamma
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Ovalbumin