Abstract
The Lyme disease agent Borrelia garinii has been suggested to be neurotrop, preferentially affecting the nervous system. We compared the secretion of interferon-gamma in response to outer surface proteins from Borrelia garinii and Borrelia afzelii in 10 patients with neuroborreliosis. In cerebrospinal fluid, stimulation with Borrelia garinii revealed higher numbers of interferon-gamma-secreting cells in all patients, whereas in blood, only five displayed higher numbers. This further strengthens the hypothesis of Borrelia garinii being associated with the development of neuroborreliosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Antigens, Bacterial / cerebrospinal fluid
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Borrelia / immunology*
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Borrelia Infections / immunology*
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Cerebrospinal Fluid / cytology
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Cerebrospinal Fluid / immunology
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Cerebrospinal Fluid / microbiology
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Child
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Female
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Humans
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Immunoassay
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Interferon-gamma / cerebrospinal fluid*
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Interferon-gamma / immunology
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Interferon-gamma / metabolism*
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Lymphocytes / immunology
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Lymphocytes / metabolism
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Lymphocytes / microbiology
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Male
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Middle Aged
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Nervous System Diseases / immunology*
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Nervous System Diseases / microbiology
Substances
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Antigens, Bacterial
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Interferon-gamma