The gamma radiation sterilization of ultrahigh molecular weight polyethylene (UHMWPE) components in air generates long-lived free radicals that oxidize slowly over time during shelf storage and after implantation. To investigate the combined effects of chemical and mechanical degradation on the mechanical behavior of UHMWPE, sterilized tensile specimens were immersed in 0.5% hydrogen peroxide solution at 37 degrees C for up to 9 months and concurrently subjected to cyclic stress levels of 0 (control), 0 to 5, and 0 to 10 MPa. After chemical and mechanical preconditioning, specimen density was measured using the density gradient column technique. The true stress-strain behavior was measured up to 0.12 true strain and characterized using a multilinear material model, the parameters of which were found to vary linearly with density and cyclic stress history. The mechanical behavior of as-irradiated and degraded UHMWPE was accurately predicted by an analytical composite beam model of the tensile specimens. The results of this study support the hypothesis that chemical and mechanical degradation affect the true stress-strain behavior of UHMWPE. In the future, the material model data presented in this study will enable more accurate prediction of the stresses and strains in UHMWPE components following gamma sterilization in air and subsequent in vivo degradation.