Conformationally constrained 1,3-diamino ketones: a series of potent inhibitors of the cysteine protease cathepsin K

J Med Chem. 1998 Sep 10;41(19):3563-7. doi: 10.1021/jm980295f.
No abstract available

MeSH terms

  • Binding Sites
  • Cathepsin K
  • Cathepsins / antagonists & inhibitors*
  • Cathepsins / metabolism
  • Crystallography, X-Ray
  • Cysteine Proteinase Inhibitors / chemical synthesis*
  • Cysteine Proteinase Inhibitors / chemistry
  • Cysteine Proteinase Inhibitors / metabolism
  • Cysteine Proteinase Inhibitors / pharmacology
  • Diamines / chemical synthesis*
  • Diamines / chemistry
  • Diamines / pharmacology
  • Ketones / chemical synthesis*
  • Ketones / chemistry
  • Ketones / pharmacology
  • Models, Molecular
  • Molecular Conformation
  • Molecular Mimicry
  • Peptides / chemistry*
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Cysteine Proteinase Inhibitors
  • Diamines
  • Ketones
  • Peptides
  • Cathepsins
  • Cathepsin K

Associated data

  • PDB/1AU3
  • PDB/1AU4