DNA repair: the Nijmegen breakage syndrome protein

C Featherstone; S P Jackson

doi:10.1016/s0960-9822(98)70392-6

DNA repair: the Nijmegen breakage syndrome protein

Curr Biol. 1998 Aug 27;8(17):R622-5. doi: 10.1016/s0960-9822(98)70392-6.

Authors

C Featherstone¹, S P Jackson

Affiliation

¹ Wellcome/Cancer Research Campaign Institute, Cambridge University, UK.

PMID: 9742394
DOI: 10.1016/s0960-9822(98)70392-6

Abstract

The gene mutated in Nijmegen breakage syndrome, a chromosome instability disorder, has been identified and sequenced. The protein product of this gene forms a complex with hMre11 and hRad50--proteins that are involved in repairing double-strand breaks in DNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Abnormalities, Multiple / genetics*
Cell Cycle Proteins / physiology*
Chromosome Breakage*
DNA Repair / physiology*
Humans
Nuclear Proteins*
Syndrome

Substances

Cell Cycle Proteins
NBN protein, human
Nuclear Proteins