Use of swine model in transplantation of vascularized skeletal tissue allografts

W P Lee; J P Rubin; S Cober; F Ierino; M A Randolph; D H Sachs

doi:10.1016/s0041-1345(98)00801-x

Use of swine model in transplantation of vascularized skeletal tissue allografts

Transplant Proc. 1998 Sep;30(6):2743-5. doi: 10.1016/s0041-1345(98)00801-x.

Authors

W P Lee¹, J P Rubin, S Cober, F Ierino, M A Randolph, D H Sachs

Affiliation

¹ Plastic Surgery Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA.

PMID: 9745559
DOI: 10.1016/s0041-1345(98)00801-x

Abstract

Permanent tolerance to vascularized skeletal tissue allografts can be induced in miniature swine with minor antigen differences using a 12-day course of CsA. Demonstration of skeletal tissue allograft survival in a large animal model without long-term immunosuppression represents an important step toward transplantation of skeletal tissue allografts in humans.

MeSH terms

Anastomosis, Surgical
Animals
Bone Transplantation / immunology
Bone Transplantation / physiology
Cyclosporine / therapeutic use*
Femoral Artery / surgery
Femoral Artery / transplantation
Femoral Vein / surgery
Femoral Vein / transplantation
Graft Survival
Hindlimb / transplantation*
Histocompatibility Testing
Humans
Immunosuppression Therapy / methods
Muscle, Skeletal / transplantation
Skin Transplantation / immunology
Skin Transplantation / physiology*
Swine
Swine, Miniature
Transplantation, Homologous / immunology
Transplantation, Homologous / methods*
Transplantation, Homologous / physiology

Substances

Cyclosporine