Abstract
Two new porphinoids, tolyporphins J (1) and K (2), have been isolated from the terrestrial cyanobacterium, Tolypothrix nodosa (HT-58-2) and identified by NMR and mass spectral analysis. The activities of tolyporphins J and K in cell sensitization and drug accumulation assays for multidrug resistance (MDR) reversal were compared with those of tolyporphin A. Unusual NMR spectroscopic shifts were observed for tolyporphin J (1) in CDCl3.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antibiotics, Antineoplastic / pharmacology*
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Chromatography, High Pressure Liquid
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Cyanobacteria / chemistry*
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Drug Resistance, Multiple*
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Porphyrins / isolation & purification
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Porphyrins / pharmacology*
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Spectrophotometry, Ultraviolet
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Tumor Cells, Cultured
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Vinblastine / metabolism
Substances
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Antibiotics, Antineoplastic
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Porphyrins
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tolyporphin J
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tolyporphin K
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Vinblastine