[Primary hyperaldosteronism and adenoma of the adrenal cortex. Suppression of aldosterone with dexamethasone]

Ann Endocrinol (Paris). 1998 Apr;59(1):20-2.
[Article in French]

Abstract

The aim of the study was to evaluate dexamethazone test in a patient with primary aldosteronism caused by an adrenocortical adenoma. We observed a 50% decrease of plasma aldosterone as in glucocorticoid suppressible aldosteronism (GSA) but absolute value of aldosterone remained higher than 40 pg/ml. Basal plasma and urinary values of 18 OXO and 18 OH cortisol were not significantly elevated as in GSA. Inversely, the evaluation of 11 beta-hydroxylase activity of mineralocorticoids was in favor of a benign adrenal tumor.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / complications*
  • Adrenal Cortex Neoplasms / complications*
  • Aldosterone / blood*
  • Aldosterone / urine
  • Cortisone / analogs & derivatives
  • Cortisone / blood
  • Dexamethasone / therapeutic use*
  • Hormones / therapeutic use*
  • Humans
  • Hyperaldosteronism / blood
  • Hyperaldosteronism / drug therapy*
  • Hyperaldosteronism / etiology*
  • Male
  • Middle Aged
  • Mineralocorticoids / blood

Substances

  • Hormones
  • Mineralocorticoids
  • 18-hydroxycortisone
  • Aldosterone
  • Dexamethasone
  • Cortisone