The Wechsler Adult Intelligence Scale-Revised as a Neuropsychological Instrument (WAIS-R NI) provides methods to uniformly interpret atypical responses or response patterns. To date, little research has examined the primary population for which the supplemental measures of the WAIS-R NI were intended. The purpose of the present study was to compare the performance of individuals with brain injuries versus healthy adults on the supplemental measures of the WAIS-R NI. Forty-nine healthy adults and 45 individuals with brain injuries were tested. MANOVA indicated a significant main effect for group membership and the results suggest the WAIS-R NI supplemental measures differentiate individuals with brain injuries from healthy adults.