NaCl-preferring NZB/B1NJ mice and NaCl-avoiding CBA/J mice have similar amiloride inhibition of chorda tympani responses to NaCl

Chem Senses. 1998 Aug;23(4):411-5. doi: 10.1093/chemse/23.4.411.

Abstract

Integrated chorda tympani nerve responses to NaCl were studied in two mouse strains, an NaCl-preferring NZB/B1NJ and an NaCl-avoiding CBA/J. The NaCl responses of both strains had similar magnitude and were suppressed by amiloride to a similar extent. This suggests that peripheral gustatory responsiveness to NaCl is not the only mechanism underlying mouse strain variation in NaCl acceptance.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amiloride / pharmacology*
  • Animals
  • Chorda Tympani Nerve / drug effects*
  • Chorda Tympani Nerve / physiology
  • Diuretics / pharmacology*
  • Drug Interactions
  • Food Preferences
  • Male
  • Mice
  • Mice, Inbred CBA
  • Mice, Inbred NZB
  • Sodium Chloride / antagonists & inhibitors*
  • Sodium Chloride / pharmacology*
  • Species Specificity
  • Taste

Substances

  • Diuretics
  • Sodium Chloride
  • Amiloride