Abstract
The authors report the first DNA-based diagnosis of Bartonella henselae cultured from a brain lesion in a patient with acquired immune deficiency syndrome. This human immunodeficiency virus-infected patient presented with altered mental status, fever, and diabetes insipidus. Magnetic resonance imaging revealed multifocal parenchymal and leptomeningeal involvement, which was confirmed on studies of tissue biopsy samples. Using the polymerase chain reaction and gene sequencing techniques, the authors definitively demonstrated the presence of B. henselae in the brain tissue biopsy specimen.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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AIDS-Related Opportunistic Infections / diagnosis*
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AIDS-Related Opportunistic Infections / physiopathology
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Adult
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Angiomatosis, Bacillary / diagnosis*
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Angiomatosis, Bacillary / physiopathology
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Arachnoid / microbiology
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Bartonella henselae / genetics
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Bartonella henselae / isolation & purification*
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Brain Diseases / microbiology*
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Brain Diseases / physiopathology
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Cognition / physiology
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DNA, Bacterial / analysis
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DNA, Bacterial / genetics
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Diabetes Insipidus / physiopathology
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Fever / physiopathology
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Humans
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Immunocompromised Host*
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Magnetic Resonance Imaging
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Male
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Meningitis, Bacterial / diagnosis
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Meningitis, Bacterial / physiopathology
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Pia Mater / microbiology
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Polymerase Chain Reaction*