Abstract
A 67-year-old woman was admitted for intestinal pseudoobstruction associated with peripheral sensitive neuropathy. Jejunal biopsies performed during laparotomy, showed axonal degeneration and lympho-plasmocytic infiltration in myenteric plexus. High titer of seric anti-Hu antibodies suggested a paraneoplastic syndrome. Thoracic CT scan showed mediastinal lymph nodes. Their histological examination confirmed the diagnosis of metastatic small-cell lung carcinoma. Her condition gradually deteriorated despite supportive parenteral nutrition, chemotherapy, steroids and intravenous immunoglobulins. She died 12 months after the onset of symptoms.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Aged
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Antibodies / analysis
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Biopsy
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Carcinoma, Small Cell / complications*
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Carcinoma, Small Cell / immunology
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Carcinoma, Small Cell / pathology
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ELAV Proteins
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Female
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Humans
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Intestinal Pseudo-Obstruction / complications*
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Intestinal Pseudo-Obstruction / immunology
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Jejunum / innervation
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Jejunum / pathology
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Laparotomy
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Lung Neoplasms / complications*
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Lung Neoplasms / immunology
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Lung Neoplasms / pathology
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Nerve Tissue Proteins*
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Paraneoplastic Syndromes / complications*
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Paraneoplastic Syndromes / immunology
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RNA-Binding Proteins / immunology*
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Radiography, Thoracic
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Retrograde Degeneration
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Tomography, X-Ray Computed
Substances
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Antibodies
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ELAV Proteins
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Nerve Tissue Proteins
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RNA-Binding Proteins