Genomic structure of a novel human gene (XYLB) on chromosome 3p22-->p21.3 encoding a xylulokinase-like protein

M Tamari; Y Daigo; S Ishikawa; Y Nakamura

doi:10.1159/000015076

Genomic structure of a novel human gene (XYLB) on chromosome 3p22-->p21.3 encoding a xylulokinase-like protein

Cytogenet Cell Genet. 1998;82(1-2):101-4. doi: 10.1159/000015076.

Authors

M Tamari¹, Y Daigo, S Ishikawa, Y Nakamura

Affiliation

¹ Laboratory of Molecular Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

PMID: 9763671
DOI: 10.1159/000015076

Abstract

We isolated a novel human cDNA of 1963 nucleotides that included an open reading frame encoding a protein of 528 amino acids. Homology analysis indicated that the predicted gene product, XYLB, bore 22% identity to the xylulokinase of Haemophilus influenzae that plays an important role in energy metabolism. The gene consists of 18 exons and spans about 28 kb of genomic DNA on chromosome 3p21.3.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Blotting, Northern
Chromosomes, Human, Pair 3*
Cloning, Molecular
Cosmids
DNA, Complementary / genetics
Exons
Genome, Human
Humans
Introns
Molecular Sequence Data
Phosphotransferases (Alcohol Group Acceptor) / genetics*
RNA Splicing
RNA, Messenger / analysis
Sequence Homology, Amino Acid

Substances

DNA, Complementary
RNA, Messenger
Phosphotransferases (Alcohol Group Acceptor)
xylulokinase