Glycosidopyrroles. Part 3. Effect of the benzocondensation on acyclic derivatives: 1-(2-hydroxyethoxy) methylindoles as potential antiviral agents

A M Almerico; P Barraja; P Diana; G Cirrincione; F Mingoia; C Musiu; G Perra; M Putzolu; M E Marongiu

doi:10.1016/s0014-827x(98)00042-1

Glycosidopyrroles. Part 3. Effect of the benzocondensation on acyclic derivatives: 1-(2-hydroxyethoxy) methylindoles as potential antiviral agents

Farmaco. 1998 Jun 30;53(6):409-14. doi: 10.1016/s0014-827x(98)00042-1.

Authors

A M Almerico¹, P Barraja, P Diana, G Cirrincione, F Mingoia, C Musiu, G Perra, M Putzolu, M E Marongiu

Affiliation

¹ Istituto Farmacochimico, Università degli Studi, Palermo, Italy.

PMID: 9764473
DOI: 10.1016/s0014-827x(98)00042-1

Abstract

The new of 1-(2-hydroxyethoxy)methylindole derivatives 3a-i were prepared in good yields. None of them showed any significant anti-HIV activity and therefore the benzocondensation between the 2 and 3 positions of the pyrrole ring definitely reduced the weak activity found in the analogues 1a-c.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-HIV Agents / chemistry*
Anti-HIV Agents / pharmacology
Cell Line
Chlorocebus aethiops
Cytopathogenic Effect, Viral / drug effects
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
HIV-1 / drug effects
HIV-1 / pathogenicity
Humans
Indoles / chemistry*
Microbial Sensitivity Tests
Pyrroles / chemistry*
Pyrroles / pharmacology
Vero Cells
Virus Replication / drug effects

Substances

Anti-HIV Agents
Indoles
Pyrroles