Carbamazepine intoxication with negative myoclonus after the addition of clobazam

Epilepsia. 1998 Oct;39(10):1115-8. doi: 10.1111/j.1528-1157.1998.tb01299.x.

Abstract

We report a case a carbamazepine (CBZ) intoxication with negative myoclonus that occurred 4 weeks after clobazam (CLB) had been added to a stable regimen of CBZ and topiramate (TPM). Both CBZ and CBZ-epoxide (CBZ-E) blood levels were elevated, and the symptoms resolved quickly when CBZ dosage was reduced and CLB discontinued. CLB was reintroduced a year later with the patient's consent, and the time course of the interaction was studied: CBZ and CBZ-E levels increased slowly over 12 days. The interaction is thus probably related to the progressive increase in Nor-CLB.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Anxiety Agents*
  • Anticonvulsants / adverse effects*
  • Anticonvulsants / blood
  • Anticonvulsants / therapeutic use
  • Benzodiazepines*
  • Benzodiazepinones / adverse effects*
  • Benzodiazepinones / blood
  • Benzodiazepinones / therapeutic use
  • Carbamazepine / blood
  • Carbamazepine / poisoning*
  • Carbamazepine / therapeutic use
  • Clobazam
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Interactions
  • Drug Therapy, Combination
  • Electroencephalography / drug effects
  • Epilepsy / blood
  • Epilepsy / drug therapy*
  • Humans
  • Male
  • Myoclonus / chemically induced*
  • Myoclonus / prevention & control

Substances

  • Anti-Anxiety Agents
  • Anticonvulsants
  • Benzodiazepinones
  • Benzodiazepines
  • Clobazam
  • Carbamazepine