Abstract
The mRNA differential display method detected increased expression of the mRNA of an immune recognition antigen known as Ly-6A/E after malignant transformation of the murine squamous cell carcinoma line Pam 212. Subsequent loss of expression of Ly-6A/E occurred with metastatic tumor progression of Pam in vivo. Ly-6 molecules have been implicated in immune cell recognition and signal transduction and are homologous to the human E48 SCC antigen that has been shown to be involved in cell-cell recognition. These observations suggest that loss of Ly-6A/E antigen may contribute to tumor progression and metastasis of squamous cell carcinoma through decreased tumor-lymphocyte or tumor-tumor recognition.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antigens, Ly / analysis
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Antigens, Ly / genetics*
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Antigens, Neoplasm / analysis
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Antigens, Neoplasm / genetics
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Biomarkers, Tumor / analysis
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Biomarkers, Tumor / genetics
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Carcinoma, Squamous Cell / genetics
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Carcinoma, Squamous Cell / immunology*
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Carcinoma, Squamous Cell / secondary
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Cell Adhesion Molecules / analysis
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Cell Adhesion Molecules / genetics*
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Cell Communication / genetics
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Cell Line, Transformed
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Cell Transformation, Neoplastic / genetics*
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Disease Progression
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GPI-Linked Proteins
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Gene Expression Regulation, Neoplastic*
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Glycoproteins / analysis
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Glycoproteins / genetics*
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Hematopoietic Stem Cells / immunology*
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Humans
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Keratinocytes
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Lymphocytes / immunology
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Membrane Proteins / analysis
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Membrane Proteins / genetics*
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Mice
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Mice, Inbred BALB C
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Neoplasm Transplantation
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RNA, Messenger / analysis
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RNA, Messenger / genetics
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Serpins / analysis
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Serpins / genetics
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Signal Transduction / genetics
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Tumor Cells, Cultured
Substances
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Antigens, Ly
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Antigens, Neoplasm
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Biomarkers, Tumor
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Cell Adhesion Molecules
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GPI-Linked Proteins
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Glycoproteins
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LY6D protein, human
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Ly6a protein, mouse
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Membrane Proteins
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RNA, Messenger
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Serpins
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squamous cell carcinoma-related antigen