Multiple stress fractures in a scleroderma patient on methotrexate therapy

M Singwe; L Le Gars; A Karneff; A Prier; G Kaplan

Multiple stress fractures in a scleroderma patient on methotrexate therapy

Rev Rhum Engl Ed. 1998 Jul-Sep;65(7-9):508-10.

Authors

M Singwe¹, L Le Gars, A Karneff, A Prier, G Kaplan

Affiliation

¹ Rheumatology Department, Saint Antoine Teaching Hospital, Paris, France.

PMID: 9785399

Abstract

A patient on methotrexate therapy for scleroderma developed four stress fractures within a period of 13 months. She was not on steroid therapy and had no risk factors for osteoporosis. A review of the literature found 13 cases of stress fractures under methotrexate therapy. Whether methotrexate can induce bone changes remains controversial.

Publication types

Case Reports
Review

MeSH terms

Female
Folic Acid Antagonists / adverse effects*
Follow-Up Studies
Fractures, Spontaneous / chemically induced*
Fractures, Spontaneous / diagnosis
Fractures, Stress / chemically induced*
Fractures, Stress / diagnosis
Humans
Methotrexate / adverse effects*
Middle Aged
Scleroderma, Systemic / complications*
Scleroderma, Systemic / drug therapy

Substances

Folic Acid Antagonists
Methotrexate