Human genes for KNSL4 and MAZ are located close to one another on chromosome 16p11.2

Genomics. 1998 Sep 15;52(3):374-7. doi: 10.1006/geno.1998.5452.

Abstract

KNSL4 (Kid; kinesin-like DNA-binding protein) is a member of the kinesin family that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Myc-associated zinc finger protein (MAZ) participates in both the initiation and the termination of transcription of target genes. We isolated genomic DNA clones that encoded KNSL4 and MAZ from a human cosmid library. Sequence analysis revealed that the two genes were very close to one another. The distance between the two genes was only 1. 2 kb, and this intervening 1.2-kb region was extremely GC-rich. The gene for KNSL4 spanned 16 kb and consisted of 14 exons and 13 introns, while the gene for MAZ spanned 6 kb and consisted of 5 exons and 4 introns. The two genes were mapped to chromosome 16p11.2 by fluorescence in situ hybridization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, Pair 16 / genetics*
  • Cloning, Molecular
  • DNA-Binding Proteins / genetics*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Kinesins / genetics*
  • Molecular Sequence Data
  • RNA Splicing / genetics
  • Restriction Mapping
  • Sequence Analysis, DNA
  • Transcription Factors / genetics*
  • Zinc Fingers / genetics

Substances

  • DNA-Binding Proteins
  • KIF22 protein, human
  • Transcription Factors
  • c-MYC-associated zinc finger protein
  • Kinesins

Associated data

  • GENBANK/D89880