Chlorambucil synergizes with purine analogs in inducing in vitro cytotoxicity in B-cell chronic lymphocytic leukemia

Haematologica. 1998 Aug;83(8):756-7.

Abstract

Combinations of different drug concentrations of CLB + FAMP and CLB + 2-CDA were synergistic in, respectively, 42.9% and 34.8%. At leukemic cell survival < or = 50%, 16.4% and 23.4% of all combinations were synergistic in the 2-CDA and FAMP groups, respectively. A significantly higher mean value of antagonistic interactions was observed in the 2-CDA group (p = 0.037).

Publication types

  • Comparative Study
  • Letter

MeSH terms

  • Antimetabolites, Antineoplastic / pharmacology*
  • Antineoplastic Agents, Alkylating / pharmacology*
  • Chlorambucil / pharmacology*
  • Cladribine / pharmacology*
  • Drug Screening Assays, Antitumor
  • Drug Synergism
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
  • Neoplastic Stem Cells / drug effects*
  • Tumor Cells, Cultured / drug effects
  • Vidarabine / analogs & derivatives*
  • Vidarabine / pharmacology

Substances

  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents, Alkylating
  • Chlorambucil
  • Cladribine
  • Vidarabine
  • fludarabine