Abstract
STCP-1 stimulated T cell chemoattractant protein-1 (STCP-1) (macrophage-derived chemokine; MDC), a recently described CC chemokine for chronically activated T lymphocytes, was found to act specifically on a subset of memory CD4 lymphocytes that displayed a Th2 cytokine profile. Also, STCP-1, thymus and activation regulated chemokine (TARC), eotaxin, and eotaxin-2 acted specifically on in vitro derived Th2 lymphocytes, while IP-10 (IFN-gamma-inducible 10-kDa protein) showed some preference for Th1 lymphocytes. The corresponding receptors for eotaxin, TARC, and IP-10 are also differentially expressed on Th1 and Th2 lymphocytes. In desensitization Ca flux experiments, TARC and STCP-1 bound to a common receptor and therefore at least one chemokine receptor for STCP-1 is CCR4. STCP-1 expression is restricted to immune cells. Dendritic cells, B cells, and macrophages produce STCP-1 constitutively, while NK cells, monocytes, and CD4 lymphocytes produce STCP-1 upon appropriate stimulation. Production of STCP-1 is positively modulated by Th2 cytokines IL-4 and IL-13 but inhibited by IL-10.
MeSH terms
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Animals
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B-Lymphocytes / metabolism
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Calcium Signaling
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Chemokine CCL11
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Chemokine CCL17
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Chemokine CCL22
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Chemokine CCL24
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Chemokine CCL5 / pharmacology
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Chemokine CXCL10
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Chemokines / pharmacology*
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Chemokines, CC / biosynthesis
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Chemokines, CC / pharmacology
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Chemokines, CC / physiology*
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Chemokines, CXC / pharmacology
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Chemotaxis, Leukocyte / drug effects*
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Cytokines / pharmacology
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Dendritic Cells / metabolism
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Feedback
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Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology
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Humans
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Immunologic Memory*
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Interleukin-10 / pharmacology
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Interleukin-13 / pharmacology
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Interleukin-13 / physiology*
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Interleukin-4 / pharmacology
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Interleukin-4 / physiology*
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Killer Cells, Natural / metabolism
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Lymphocyte Activation*
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Macrophages / metabolism
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Mice
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Mice, Inbred BALB C
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Monocytes / drug effects*
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Monocytes / metabolism
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Receptors, CCR3
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Receptors, CCR4
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Receptors, CXCR3
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Receptors, Chemokine / analysis
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Receptors, Chemokine / drug effects*
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Receptors, Chemokine / physiology
Substances
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CCL11 protein, human
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CCL17 protein, human
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CCL22 protein, human
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CCL24 protein, human
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CCR3 protein, human
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CCR4 protein, human
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CXCR3 protein, human
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Ccl11 protein, mouse
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Ccl17 protein, mouse
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Ccl22 protein, mouse
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Ccl24 protein, mouse
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Ccr3 protein, mouse
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Ccr4 protein, mouse
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Chemokine CCL11
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Chemokine CCL17
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Chemokine CCL22
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Chemokine CCL24
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Chemokine CCL5
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Chemokine CXCL10
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Chemokines
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Chemokines, CC
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Chemokines, CXC
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Cxcr3 protein, mouse
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Cytokines
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Interleukin-13
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Receptors, CCR3
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Receptors, CCR4
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Receptors, CXCR3
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Receptors, Chemokine
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Interleukin-10
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Interleukin-4
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Granulocyte-Macrophage Colony-Stimulating Factor