65 knee arthroplasties in 60 patients (5 x both sided, 49 x female, 11 x male) with a Genesis Total Knee System (54 x cemented, 6 x cementless, 4 x tibial cemented/femoral cementless, 1 x tibial cementless/femoral cemented) were evaluated according to the Knee Society Score and the HSS Score with a medium follow up of 4 years und 5 months (3 years and 4 months to 5 years and 11 months). In 48 patients the diagnosis was gonarthrosis, in 17 patients it was rheumatoid arthritis. The medium postoperative Knee Score was 80.9 points, the Function Score was 73.7 points. The HSS Score obtained 80.9 points. 87.7% of the patients were excellent or good. The Genesis Total Knee arthroplasty has proved to be reliable for osteoarthritis and rheumatoid arthritis in medium term.