Genetic characterization of pepP, which encodes an aminopeptidase P whose deficiency does not affect Lactococcus lactis growth in milk, unlike deficiency of the X-prolyl dipeptidyl aminopeptidase

Appl Environ Microbiol. 1998 Nov;64(11):4591-5. doi: 10.1128/AEM.64.11.4591-4595.1998.

Abstract

We sequenced the pepP gene of Lactococcus lactis, which encodes an aminopeptidase P (PepP), and demonstrated that the X-prolyl dipeptidyl aminopeptidase PepX plays a more important role than PepP in nitrogen nutrition. PepP shares homology with methionine aminopeptidases and could play a role in the maturation of nascent proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Aminopeptidases / biosynthesis
  • Aminopeptidases / chemistry
  • Aminopeptidases / genetics*
  • Aminopeptidases / metabolism
  • Animals
  • Chromosome Mapping
  • Chromosomes, Bacterial
  • Conserved Sequence
  • Genes, Bacterial*
  • Lactococcus lactis / enzymology*
  • Lactococcus lactis / genetics*
  • Lactococcus lactis / growth & development
  • Methionyl Aminopeptidases
  • Milk / microbiology*
  • Molecular Sequence Data
  • Multigene Family
  • Phenotype
  • Sequence Alignment
  • Sequence Homology, Amino Acid

Substances

  • Aminopeptidases
  • Methionyl Aminopeptidases
  • X-Pro aminopeptidase

Associated data

  • GENBANK/Y08842