Cellular and molecular regulation of eosinophil trafficking to the lung

S P Hogan; A W Mould; J M Young; M E Rothenberg; A J Ramsay; K Matthaei; I G Young; P S Foster

doi:10.1046/j.1440-1711.1998.00766.x

Cellular and molecular regulation of eosinophil trafficking to the lung

Immunol Cell Biol. 1998 Oct;76(5):454-60. doi: 10.1046/j.1440-1711.1998.00766.x.

Authors

S P Hogan¹, A W Mould, J M Young, M E Rothenberg, A J Ramsay, K Matthaei, I G Young, P S Foster

Affiliation

¹ Division of Biochemistry, John Curtin School of Medical Research, Australian National University, Acton, Australian Capital Territory.

PMID: 9797467
DOI: 10.1046/j.1440-1711.1998.00766.x

Abstract

Airway inflammation is central to the pathogenesis of allergic asthma, and molecules that mediate this process obviously represent targets for therapy. In the present article, we discuss our experiments, which point to CD4+ T cells and IL-5-driven eosinophilia as potential targets for the relief of bronchial hyperreactivity in late-phase asthma.

MeSH terms

Animals
Asthma / immunology*
CD4-Positive T-Lymphocytes / physiology
Cell Movement / physiology*
Chemokine CCL11
Chemokines, CC*
Cytokines / physiology
Disease Models, Animal
Eosinophils / physiology*
Immunity, Cellular
Interleukin-4 / physiology*
Interleukin-5 / physiology*
Lung / immunology
Mice
Pulmonary Eosinophilia / immunology

Substances

Ccl11 protein, mouse
Chemokine CCL11
Chemokines, CC
Cytokines
Interleukin-5
Interleukin-4