Abstract
Tctex3 showing restricted expression in male germ cells has been isolated during the process of chromosome walking in the mouse t-complex region. The total sequence of Tctex3 cDNA predicts a protein of 580 amino acids with two C4HC3 type PHD fingers. The region containing this conserved motif is shared among members of the Polycomblike proteins that include the mouse M96 and Drosophila Polycomblike. A partial cDNA for a human homolog of Tctex3, HUTEX3, has also been isolated. Mouse Tctex3 gene was mapped adjacent to Tsc2 gene on mouse Chromosome (Chr) 17, and HUTEX3 was located closely to HSET gene in the HLA class II region of chromosome 6.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Chromosome Mapping
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Chromosomes, Human, Pair 6
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DNA-Binding Proteins
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Drosophila Proteins*
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Drosophila melanogaster
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Humans
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Intracellular Signaling Peptides and Proteins*
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Male
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Mice
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Microtubule-Associated Proteins*
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Molecular Sequence Data
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Nuclear Proteins / biosynthesis*
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Nuclear Proteins / genetics
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Polycomb-Group Proteins
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Rats
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Repressor Proteins / analysis
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Repressor Proteins / genetics
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Testis / metabolism*
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Transcription Factors
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Ubiquitin-Protein Ligases
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Xenopus laevis
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t-Complex Genome Region
Substances
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DNA-Binding Proteins
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Drosophila Proteins
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Intracellular Signaling Peptides and Proteins
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Microtubule-Associated Proteins
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Nuclear Proteins
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Pcl protein, Drosophila
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Phf1 protein, mouse
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Polycomb-Group Proteins
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Repressor Proteins
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Transcription Factors
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PPP1R11 protein, human
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Ubiquitin-Protein Ligases