Gastritis is an infrequent manifestation of infection by cytomegalovirus (CMV) in a healthy host. This complication is usually associated to a mononucleosic syndrome during the course of a disseminated infection. Macroscopically, it presents with edema and mucosal congestion, multiple erosions or ulcers. Histologic examination of the endoscopic biopsies allows the etiologic diagnosis to be established in most cases. In immunocompetent patients the clinical course of gastritis by CMV is usually self-limited. We herein present two immunocompetent patients with gastric ulcerous disease as the only manifestation of CMV infection. Both patients required antiviral treatment due to refractoryness to the antisecretor treatment and one case evolved to pyloric stenosis requiring surgery.