Abstract
Intracisternal atropine and mecamylamine failed to modify baroreflex sensitivity in dogs, suggesting a lack of cholinergic neurons integrated in baroreflex pathways. Conversely, neostigmine lowered baroreflex sensitivity suggesting a putative cholinergic modulation.
MeSH terms
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Acetylcholine / physiology*
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Animals
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Atropine / pharmacology
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Baroreflex / drug effects
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Baroreflex / physiology*
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Blood Pressure / drug effects
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Cholinesterase Inhibitors / pharmacology
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Dogs
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Female
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Male
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Mecamylamine / pharmacology
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Muscarinic Antagonists / pharmacology
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Neostigmine / pharmacology
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Nicotinic Antagonists / pharmacology
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Receptors, Muscarinic / metabolism
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Receptors, Nicotinic / metabolism
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Vasodilator Agents / pharmacology
Substances
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Cholinesterase Inhibitors
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Muscarinic Antagonists
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Nicotinic Antagonists
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Receptors, Muscarinic
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Receptors, Nicotinic
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Vasodilator Agents
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Neostigmine
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Mecamylamine
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Atropine
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Acetylcholine