Endogenous central cholinergic systems and baroreflex modulation in the conscious dog

Fundam Clin Pharmacol. 1998;12(6):643-5. doi: 10.1111/j.1472-8206.1998.tb00999.x.

Abstract

Intracisternal atropine and mecamylamine failed to modify baroreflex sensitivity in dogs, suggesting a lack of cholinergic neurons integrated in baroreflex pathways. Conversely, neostigmine lowered baroreflex sensitivity suggesting a putative cholinergic modulation.

MeSH terms

  • Acetylcholine / physiology*
  • Animals
  • Atropine / pharmacology
  • Baroreflex / drug effects
  • Baroreflex / physiology*
  • Blood Pressure / drug effects
  • Cholinesterase Inhibitors / pharmacology
  • Dogs
  • Female
  • Male
  • Mecamylamine / pharmacology
  • Muscarinic Antagonists / pharmacology
  • Neostigmine / pharmacology
  • Nicotinic Antagonists / pharmacology
  • Receptors, Muscarinic / metabolism
  • Receptors, Nicotinic / metabolism
  • Vasodilator Agents / pharmacology

Substances

  • Cholinesterase Inhibitors
  • Muscarinic Antagonists
  • Nicotinic Antagonists
  • Receptors, Muscarinic
  • Receptors, Nicotinic
  • Vasodilator Agents
  • Neostigmine
  • Mecamylamine
  • Atropine
  • Acetylcholine