Application of lipids and plasmid design for gene delivery to mammalian cells

Curr Opin Biotechnol. 1998 Oct;9(5):480-5. doi: 10.1016/s0958-1669(98)80033-5.

Abstract

Cationic lipids are widely used for in vitro gene transfer due to their efficiency. The major challenges for the improvement of in vivo cationic lipid-mediated gene delivery reside in the design of more biocompatible lipoplexes mimicking viral-mediated gene delivery and in understanding the fate of the lipoplexes within the cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biotechnology
  • Cations
  • Chemical Phenomena
  • Chemistry, Physical
  • Drug Design
  • Gene Transfer Techniques*
  • Genetic Vectors
  • Humans
  • Lipids / chemistry*
  • Plasmids / genetics*

Substances

  • Cations
  • Lipids