CD8 T cells in HIV infection: mechanisms of immunity

Hosp Pract (1995). 1998 Nov 15;33(11):105-8, 111-2, 115-7 passim. doi: 10.3810/hp.1998.11.116.

Abstract

CD8 lymphocytes probably play a key role in the immunologic defense against HIV. The evidence is that they control viral replication by at least two mechanisms: direct antigen-specific cytolysis, which appears to be required for optimal suppression, and release of soluble antiviral factors. New therapeutic strategies are taking into account mechanisms by which the virus may evade CD8 control.

Publication types

  • Review

MeSH terms

  • CD8-Positive T-Lymphocytes / immunology*
  • Chemokines / immunology
  • Disease Progression
  • HIV Infections / blood
  • HIV Infections / immunology*
  • HIV Infections / therapy
  • HIV Infections / virology
  • Humans
  • Time Factors
  • Viral Load
  • Virus Replication / immunology

Substances

  • Chemokines