Abstract
Abnormal uterine bleeding is a common, debilitating condition. Dysfunctional uterine bleeding (DUB) is the diagnosis given to women with abnormal uterine bleeding in whom no clear etiology can be identified. DUB has been observed in both ovulatory and anovulatory cycles. Medical treatments include nonsteroidal anti-inflammatory drugs, oral contraceptive pills, progestins, danazol (a synthetic androgen), GnRH agonists, and antifibrinolytic drugs. The drawback to medical therapy, in addition to side effects, is that the benefit lasts only while the patient takes the medication. Surgical options have concentrated mainly on endometrial ablation and hysterectomy, and it is unclear whether one is superior to the other in terms of long-term outcome and patient satisfaction. Newer and less invasive ablation techniques, such as thermal balloon ablation, offer more treatment alternatives.
MeSH terms
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Adolescent
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Adult
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Antifibrinolytic Agents / adverse effects
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Antifibrinolytic Agents / therapeutic use
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Contraceptives, Oral / adverse effects
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Contraceptives, Oral / therapeutic use
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Danazol / adverse effects
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Danazol / therapeutic use
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Endometrium / surgery
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Estrogen Antagonists / adverse effects
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Estrogen Antagonists / therapeutic use
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Female
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Gonadotropin-Releasing Hormone / agonists
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Humans
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Hysterectomy
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Menorrhagia / diagnosis
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Menorrhagia / drug therapy
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Menorrhagia / surgery
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Menorrhagia / therapy*
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Middle Aged
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Ovulation / physiology
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Patient Satisfaction
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Progestins / adverse effects
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Progestins / therapeutic use
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Treatment Outcome
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antifibrinolytic Agents
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Contraceptives, Oral
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Estrogen Antagonists
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Progestins
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Gonadotropin-Releasing Hormone
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Danazol