Pyrazole analogues of prazosin

Farmaco. 1998 Jul 30;53(7):519-24. doi: 10.1016/s0014-827x(98)00052-4.

Abstract

A series of analogues of prazosin, in which 1-methyl or 1-phenylpyrazole moieties were substituted for the furan ring, were synthesized and studied for their alpha 1-adrenoceptor antagonist activity. The role of the five member heterocyclic substructures in determining the affinity for the alpha 1-receptor is briefly discussed.

Publication types

  • Comparative Study

MeSH terms

  • Adrenergic alpha-Antagonists / chemical synthesis*
  • Adrenergic alpha-Antagonists / chemistry*
  • Adrenergic alpha-Antagonists / pharmacology
  • Animals
  • Models, Molecular
  • Muscle, Smooth, Vascular / drug effects
  • Prazosin / analogs & derivatives*
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / chemistry*
  • Pyrazoles / pharmacology
  • Rats
  • Structure-Activity Relationship

Substances

  • Adrenergic alpha-Antagonists
  • Pyrazoles
  • Prazosin