Abstract
The genetic characterization of a foscarnet-resistant strain of varicella-zoster virus (VZV) that was isolated from a patient with AIDS is reported. Compared with the sequence of the Dumas reference strain, this strain, which was isolated from a patient in whom foscarnet treatment failed, had two point mutations. The emergence of one of the mutations, which includes a change from a glutamic acid to a lysine at position 512 in the DNA polymerase, suggests that this mutation is implicated in the VZV foscarnet resistance. The other mutation, which replaces serine 863 by a glycine, is also present in 2 susceptible strains--Oka and a wild-type isolate.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS-Related Opportunistic Infections / virology
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Adult
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Amino Acid Sequence
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Amino Acid Substitution
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Antiviral Agents / pharmacology*
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Base Sequence
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DNA Primers / genetics
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DNA-Directed DNA Polymerase / genetics*
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Drug Resistance, Microbial / genetics
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Foscarnet / pharmacology*
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Herpes Zoster / complications
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Herpes Zoster / virology
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Herpesvirus 3, Human / drug effects*
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Herpesvirus 3, Human / enzymology*
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Herpesvirus 3, Human / genetics
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Humans
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Molecular Sequence Data
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Point Mutation
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Polymerase Chain Reaction
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Sequence Homology, Amino Acid
Substances
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Antiviral Agents
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DNA Primers
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Foscarnet
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DNA-Directed DNA Polymerase