Nitrogen-carbon-linked (azolylphenyl)oxazolidinones with potent antibacterial activity against the fastidious gram-negative organisms Haemophilus influenzae and Moraxella catarrhalis

J Med Chem. 1998 Dec 17;41(26):5144-7. doi: 10.1021/jm980546k.

Authors

M J Genin¹, D K Hutchinson, D A Allwine, J B Hester, D E Emmert, S A Garmon, C W Ford, G E Zurenko, J C Hamel, R D Schaadt, D Stapert, B H Yagi, J M Friis, E M Shobe, W J Adams

Affiliation

¹ Pharmacia & Upjohn, Inc., Kalamazoo, Michigan 49001, USA.

PMID: 9857083
DOI: 10.1021/jm980546k

No abstract available

MeSH terms

Administration, Oral
Animals
Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacokinetics
Anti-Bacterial Agents / pharmacology
Colony Count, Microbial
Haemophilus influenzae / drug effects*
Inhibitory Concentration 50
Injections, Intravenous
Male
Mice
Moraxella catarrhalis / drug effects*
Oxazoles / chemical synthesis*
Oxazoles / chemistry
Oxazoles / pharmacokinetics
Oxazoles / pharmacology
Pyrazoles / chemical synthesis*
Pyrazoles / chemistry
Pyrazoles / pharmacokinetics
Pyrazoles / pharmacology
Pyrroles / chemical synthesis*
Pyrroles / chemistry
Pyrroles / pharmacokinetics
Pyrroles / pharmacology
Rats
Rats, Sprague-Dawley
Staphylococcal Infections / drug therapy
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Oxazoles
PNU 171933
PNU 172576
Pyrazoles
Pyrroles