Abstract
Interleukin-10 failed to modify either the percentage of bcl-2+ cells or the number of bcl-2 molecules, or to reduce 2-chlorodeoxyadenosine- and fludarabine-induced apoptosis. The cytokine at 0.1 ng/mL induced an increase of cell survival both in the absence or in the presence of 2-chlorodeoxyadenosine, while no difference was appreciated with fludarabine.
MeSH terms
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Antimetabolites, Antineoplastic / pharmacology
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Apoptosis / drug effects*
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Cladribine / antagonists & inhibitors
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Cladribine / pharmacology
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Drug Interactions
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Drug Screening Assays, Antitumor
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Gene Expression Regulation, Leukemic / drug effects*
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Humans
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Interleukin-10 / pharmacology*
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Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
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Neoplasm Proteins / biosynthesis*
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Neoplasm Proteins / genetics
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Proto-Oncogene Proteins c-bcl-2 / biosynthesis*
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Proto-Oncogene Proteins c-bcl-2 / genetics
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Tumor Cells, Cultured / drug effects
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Vidarabine / analogs & derivatives
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Vidarabine / pharmacology
Substances
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Antimetabolites, Antineoplastic
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Neoplasm Proteins
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Proto-Oncogene Proteins c-bcl-2
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Interleukin-10
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Cladribine
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Vidarabine
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fludarabine