Topoisomerase I inhibitors from the Streptomyces sp. strain KM86-9B isolated from a marine sponge

H K Lee; D S Lee; J Lim; J S Kim; K S Im; J H Jung

doi:10.1007/BF02976766

Topoisomerase I inhibitors from the Streptomyces sp. strain KM86-9B isolated from a marine sponge

Arch Pharm Res. 1998 Dec;21(6):729-33. doi: 10.1007/BF02976766.

Authors

H K Lee¹, D S Lee, J Lim, J S Kim, K S Im, J H Jung

Affiliation

¹ Microbiology Lab., Korea Ocean Research & Development Institute, Ansan, Korea.

PMID: 9868546
DOI: 10.1007/BF02976766

Abstract

The crude extract of Streptomyces sp. strain KM86-9B, isolated from a marine sponge, displayed significant inhibition on topoisomerase I activity. Investigation of the causative components by bioactivity-directed fractionation resulted in the isolation of a series of iso- and anteiso-fatty acids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chemical Fractionation
Fatty Acids / isolation & purification
Fatty Acids / pharmacology*
Porifera / microbiology*
Streptomyces / chemistry*
Topoisomerase I Inhibitors*

Substances

Fatty Acids
Topoisomerase I Inhibitors