Abstract
Six 3-dialkylaminomethyl-1-azaanthraquinones and five 4-dialkylaminomethyl-1-azaanthraquinones were synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines. The compounds retained much of their cytotoxic activity against the multi-drug-resistant cell line (KB-V-1) as shown by resistance index.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anthraquinones / chemical synthesis
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Anthraquinones / therapeutic use*
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Anthraquinones / toxicity
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Antineoplastic Agents / therapeutic use*
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Aza Compounds / chemical synthesis
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Aza Compounds / therapeutic use*
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Aza Compounds / toxicity
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Drug Evaluation
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Humans
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Tumor Cells, Cultured
Substances
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Anthraquinones
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Antineoplastic Agents
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Aza Compounds